Monitoring Biodistribution of Exosome Therapeutics to Advance Quantitative Tracking Validation Strategies & Improve Translational Interpretation
- Implementing robust labelling and detection strategies (e.g., fluorescent, radioactive, or molecular tagging) to enable accurate in vivo tracking of exosome fate
- Addressing methodological challenges including signal dilution, label stability, and distinguishing free label from intact vesicles
- Correlating biodistribution profiles with pharmacodynamic effects to inform dosing, safety assessment, and tissue targeting strategies