CONFERENCE DAY ONE
7:30 am Check-In & Morning Coffee
8:20 am Chair’s Opening Remarks
Boosting Exosome & Extra-Cellular Vesicle Innovation & Clinical Strategy Towards the First Therapeutic Approval
8:30 am Clinical Application of Platelet-Derived Exosomes in Regenerative Medicine
Synopsis
- Introduction to Rion’s exosome-based drug product and MOA
- Current application of Rion’s technology in clinical trials
- Forward-looking application of platelet-derived exosomes
NEW DATA!
9:00 am Accelerating Exosome-Based Therapeutics: From Innovation to GMP-Ready Solution
Synopsis
- Showcasing an update on EXO Biologics’ clinical trials
- Presenting exosomes use as a safer alternative to viral drug delivery systems
- Ensuring the quality and compliance of your exosomes
NEW DATA!
9:30 am A Non-Conventional Pathway to Commercialize an EV Therapeutic
Synopsis
- MSC secretome: Cell therapy without the cells
- Navigating Direct Biologics’ pathway to phase III clinical trial
- Leveraging nature’s mechanism of action for disease mitigation
NEW DATA!
10:00 am Morning Break & Networking
Synopsis
This session is your opportunity to get face-to-face with many of the brightest minds working in the exosome and extra-cellular vesicle therapy field, and establish meaningful business relationships to pursue for the rest of the conference
Advancing Clinical EV-Based Therapeutic Programs To Achieve Improved Safety & Mechanims of Action in Patients
11:00 am Update on Cleared US FDA IND for Acute Ischemic Stroke Using Neural Stem Cell Derived EVs
Synopsis
- AB126: A first-in-class EV Therapy for stroke and CNS diseases and designed to treat stroke patients with poor prognosis post-reperfusion: A high medical-need
- IND-cleared, with preliminary work underway for the first-in-human trial
- AB126 offers a novel, multi-target solution with a clear mechanisms or action that address inflammation, immune response and repair
NEW DATA!
11:30 am Session Reserved for: Lonza
12:00 pm Clinical Advances in EV Therapies
Synopsis
- Updating the field on Aegle’s therapeutic clinical progress
- Highlighting where we go from here and overcoming key challenges
NEW DATA!
12:30 pm Lunch Break & Networking
Envisioning the Success of Exosome & Extra-Cellular Vesicles Therapies Enabled by Robust Biopharma Partnerships & Scientific Collaboration
1:30 pm Biopharma Leaders Panel Discussion: Unlocking the Next Wave of Safe & Efficient Exosome-Based Therapeutics Towards Clinical & Commercial Reality
Synopsis
This is your chance to hear from pioneering executive leaders from the exosome and extra-cellular vesicle community who will discuss their strategies, challenges, and future perspectives for exosome technology and clinically relevant therapeutic applications.
- What are the future opportunities, promising targets, and applications on the horizon for exosomes to achieve clinical success?
- What can we learn from past experiences, principles, and guidelines to roadmap and accelerate the next 5 years of therapeutic development?
- What advice can you give this room of exosome experts to reduce risk, extend cash flow, and become an investable SME?
2:15 pm Advances in EV Manufacturing: Case Studies of Fully Automated Exosome Isolation Systems
Synopsis
- Process improvements combining chromatography and TFF
- Acceleration of clinical trial-scale process development
- Focus on improved purity while maintaining high yield
2:45 pm Afternoon Break & Scientific Poster Session
Synopsis
As the discovery and development of exosomes and extra-cellular vesicle-based therapeutics continues to advance, it is essential to collaborate and share knowledge to streamline the approval process. Share your latest findings and gain insight into the cutting-edge work of your peers and promote collaboration.
Supercharging EV-Based Carrier Delivery to Ensure Efficient Targeting & Efficacious Translation Towards the Clinic
3:30 pm AI-Driven Natural Drug Delivery Platform Technology for Enhanced In Vivo Delivery
Synopsis
- Engineering Natural Nanoparticles (NNPs) using NNP Sorting Motif (NSM) for enhanced delivery
- Understanding the dynamics of engineered NNP surface proteins to recognize specific target cell types
- Elucidating the mechanism of NNP engineering through AI prediction
NEW DATA!
4:00 pm Unlocking the Potential of Multicolor EV Characterization with Flow NanoAnalyzer
Synopsis
- Reviewing the state of the art in multi-color labeling of biological nanoparticles like EVsand discuss important choices in instrumentation configuration, reagent selection, and experimental design
- The Flow Nanoanalyzer is a highly sensitive nano flow cytometry device designed specifically for the detection of nanoparticles and their associated dim fluorescent signals
- Discussing calibration for size and count of EVs, quantifications of fluorescent signals, and common experimental factors that can impact sensitivity
4:10 pm Can Extracellular Vesicles be Engineered for Muscle Delivery?
Synopsis
- Showcasing StealthX: Exosome-based platform for engineering of EVs
- Harnessing a muscle-targeting moiety to improve muscle delivery in vitro and in vivo
- Presenting possible applications of muscle-targeting EVs
NEW DATA!
4:40 pm Session Reserved for: Unchained Labs
4:50 pm MEVs (Microalgae Extracellular Vesicles) – A Universal Delivery System for RNA Therapeutics, Vaccines & Gene Therapies
Synopsis
- Introducing MEVs and MEV technology
- Showcasing the uniqueness of MEVs compared with mammalian EVs
- Demonstrating MEV potential through data-driven case studies
NEW COMPANY!